Oximum tác động như thế nào tới chất lượng tinh trùng

.Thực phẩm bổ sung Oximum - cải thiện nồng độ, chất lượng tinh trùng giúp tăng khả năng thụ thai, đem lại niềm vui cho các cặp vợ chồng hiếm muộn, vô sinh nam

Những nghiên cứu lâm sàng:

Thành phần OXIMUM:

thực phẩm chức năng oximum

Hiệu quả OXIMUM:

 
- Những thành phần của OXIMUM đã được chứng minh trên một số nghiên cứu lâm sàng và kết quả cho thấy OXIMUM cải thiện khả năng di chuyển, nồng độ, và hình thái của tinh trùng ở những người đàn ông có chỉ số tinh trùng thấp. (5),(12),(18),(19),(20).
 
- Một nghiên cứu được hiện năm 2014 ở 300 đàn ông có vấn đề sinh sản, cho thấy những thành phần của OXIMUM gia tăng đáng kể tỉ lệ thụ thai: (18)
 
·        Trong nhóm điều trị với OXIMUM, 21.8% đạt tỉ lệ thụ thai thành công (một cách tự nhiên) so với 1.7% ở nhóm điều trị bằng giả dược placebo (18).
•        Những đàn ông có chỉ số chất lượng tinh trùng thấp, đã cải thiện các chỉ số.
•        Phần lớn các trường hợp mang thai thàng công đều trong giai đoạn điều trị từ 03 – 06 tháng.
 
- Ngoài ra, thành phần OXIMUM đã cho thấy giảm tỉ lệ gốc gây oxy hóa tự do (ROS) thành phần gây tổn thương chất lượng tinh trùng.(12)

Bibliogaphical references:

(1)              R. Scout, A,et al. The effect of oral Selenium supplementation on human sperm motility. British Journal of Urology (1998), 82, 76-80
(2)              Andre Lenzi, M. D., et al. A placebo-controlled double-blind randomized trial of the use of combined L-carnitine and L-acetyl-carnitine treatment in men with asthenozoospermia. Fertility and Sterility. Vol. 81, Nº 6, Jun 2004
(3)              Ashok, A. Et al. Carnitines and male infertility. Reproductive Biomedicine on line. Vol 8, Nº 4 pp. 376-384. 2004.
(4)              Wai Yee Wong, M. D. Et al. Effects of folic acid and Zinc sulphate on male factor subfertility a double-blind, randomized, placebo-controlled trial. Fertility and Sterility. Vol 77 Nº 3. March 2002.
(5)              Costa M, Canale D, Filicori M et al. L-carnitine in idiopathic asthenozoospermia: a multicenter study. Italian Study Group on Carnitine and Male Infertility. Andrologia. 1994 May-Jun;26(3):155-159.
(6)              Giancarlo Balercia, M. D. et al. Coenzima Q 10 supplemetation in infertile men with idiopathic asthenozoospermia: and open, uncontrolled pilot study. Fertility and sterility. Vol 81. Nº 1 January 2004.
(7)              E Vicari, et al. Effects of treatment with carnitines in infertile patients with prostate-vesiculo-epididymitis. Human reproduction. Vol 16 Nº 11. pp. 2338-2342, 2001.
(8)              Suleiman SA, Elamin Ali M, Zaki ZMS, et al. Lipid peroxidation and human sperm motility: protective role of vitamin E. J Androl. 1996;17:530 – 537.
(9)              Dawson EB, Harris WA, Rankin WE, et al. Effect of ascorbic acid on male fertility. Ann N Y Acad Sci. 1987;498:312 - 323.
(10)         Padron OF, Brackett NL, Sharma RK et al. Seminal reactive oxygen species and sperm motility and morphology in men with spinal cord injury. Fertil Steril. 1997 Jun;67(6):1115-1120.
(11)         Agarwal A, Said TM. Carnitines and male infertility. Reprod BioMed Online. 2004 Apr;8(4):376–384.
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(13)         Vicari E, La Vignera S , Calogero AE. Antioxidant treatment with carnitines is effective in infertile patients with prostatovesiculoepididymitis and elevated seminal leukocyte concentrations after treatment with nonsteroidal anti-inflammatory compounds. Fertil Steril. 2002 Dec;78(6):1203-1208.
(14)         Scott R, MacPherson A, Yates RW, Hussain B, Dixon J. The effect of oral selenium supplementation on human sperm motility. Br J Urol. 1998 Jul;82(1):76-80.
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(17)         Vicari E. Effectiveness of a short-term anti-oxidative high-dose therapy on IVF program outcome in infertile male patients with previous excessive sperm radical oxygen species production persistent even following antimicrobials administered for epididymitis: preliminary results. In: International Meeting on Infertility and Assisted Reproductive Technology. Porto Carvo, Italy; June 11-14, 1997:93-97.
(18)         Cavallini G, Ferraretti AP, Gianaroli L et al. Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia. J Androl. 2004 Sep-Oct;25(5):761-770.
(19)         Lenzi A, Sgro P, Salacone P et al. A placebo-controlled double-blind randomized trial of the use of combined L-carnitine and acetyl-L-carnitine treatment in men with asthenospermia. Fertil Steril. 2004 Jun;81(6):1578-1584.
(20)         Garolla A, Maiorino M, Roverato A et al. Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels. Fertil Steril. 2005 Feb;83(2):355-361.
(21)         Gundogan M, Yeni D, Avdatek F, Fidan AF. Influence of sperm concentration on the motility, morphology, membrane and DNA integrity along with oxidative stress parameters of ram sperm during liquid storage. Urology and Nephrology Research Center, Shahid Beheshti University, Tehran, Iran.
(22)         Safarinejad MR Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men.. J Urol. 2009 Jul;182(1):237-48. Epub 2009 May 17.
(23)         Barroso G, Morshedi M, Oehninger S. Analysis of DNA fragmentation, plasma membrane translocation of phosphatidylserine and oxidative stress in human spermatozoa. Hum. Reprod. 2000; 15: 1338–44. 47: 97–101.
(24)         Zini A, Bielecki R, Phang D, Zenzes MT: Correlations between two markers of sperm DNA integrity,DNA denaturation and DNA fragmentation, in fertile and infertile men. Fertil Steril.2001;75:674-7.
(25)         Greco E, Iacobelli M, Rienzi L, Ubaldi  F, Ferrero S, Tesarik J.: Reduction of the incidence of sperm  DNA fragmentation by oral antioxidant treatment. J Androl. 2005;26:349-53.
(26)         Harper P, Elwin CE, Cederblad G. “Pharmacokinetics of intravenous and oral bolus doses of L-carnitine in healthy Subjects”. Eur J Clin Pharmacol. 1988;35(5):555-62.
(27)         Cao Y, Qu HJ, Li P, Wang CB, Wang LX, Han ZW. “Single dose administration of L-carnitine improves antioxidant activities in healthy subjects”. Tohoku J Exp Med. 2011;224(3):209-13.
(28)         Rebouche CJ. “Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism”. Ann N Y Acad Sci. 2004 Nov;1033:30-41.
(29)         Andre Lenzi, M. D., et al. A placebo-controlled double-blind randomized trial of the use of combined L-carnitine and L-acetyl-carnitine treatment in men with asthenozoospermia. Fertility and Sterility. Vol. 81, No 6, Jun 2004.
(30)         Ashok, A. Et al. Carnitines and male infertility. Reproductive Biomedicine on line. Vol 8, No 4 pp. 376-384. 2004.
(31)         Costa M, Canale D, Filicori M et al. L-carnitine in idiopathic asthenozoospermia: a multicenter study. Italian Study Group on Carnitine and Male Infertility. Andrologia. 1994 May- Jun;26(3):155-159.
(32)         Boxmeer JC, Smit M, Weber RF, Lindemans J, Romijn JC, Eijkemans MJ, Macklon NS, Steegers-Theunissen RP. Seminal plasma cobalamin significantly correlates with sperm concentration in men undergoing IVF or ICSI procedures. J Androl. 2007 Jul-Aug; 28(4):521-7. Epub 2007 Feb 7.
(33)         Omu AE, Al- Azemi MK, Kehinde EO, Anim JT, Oriowo MA, Mathew TC. Indicationas of the mechanism involved in improved sperm parameters by zinc therapy. Med Princ Pract. 2008;17(2):108-16.